Medicine

A pioneering researcher transforms our understanding of trauma and offers a bold new paradigm for healing. Trauma is a fact of life. Veterans and their families deal with the painful aftermath of combat; one in five Americans has been molested; one in four grew up with alcoholics; one in three couples have engaged in physical violence. Dr. Bessel van der Kolk, one of the world's foremost experts on trauma, has spent over three decades working with survivors. In The Body Keeps the Score, he uses recent scientific advances to show how trauma literally reshapes both body and brain, compromising sufferers' capacities for pleasure, engagement, self-control, and trust. He explores innovative treatments—from neurofeedback and meditation to sports, drama, and yoga—that offer new paths to recovery by activating the brain's natural neuroplasticity. Based on Dr. van der Kolk's own research and that of other leading specialists, The Body Keeps the Score exposes the tremendous power of our relationships both to hurt and to heal—and offers new hope for reclaiming lives.

At the height of WWI, history’s most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease. Magisterial in its breadth of perspective and depth of research and now revised to reflect the growing danger of the avian flu, The Great Influenza is ultimately a tale of triumph amid tragedy, which provides us with a precise and sobering model as we confront the epidemics looming on our own horizon. John M. Barry has written a new afterword for this edition that brings us up to speed on the terrible threat of the avian flu and suggest ways in which we might head off another flu pandemic.

“Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability.” — The New Yorker The genome's been mapped. But what does it mean? Matt Ridley’s Genome is the book that explains it what it is, how it works, and what it portends for the future Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

An alternative cover edition for this ISBN can be found here and here.The Emperor of All Maladies is a magnificent, profoundly humane “biography” of cancer - from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function.The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856 where a monk stumbles on the idea of a ‘unit of heredity’. It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds – from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes.This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to “read” and “write” the human genome – unleashing the potential to change the fates and identities of our children.Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity – and a vision of both humanity’s past and future.

The fascinating account of a pioneering ethnobotanist’s travels in the Amazon—at once a gripping adventure story, a passionate argument for conservationism, and an investigation into the healing power of plants, by the author of The What Everyone Needs to KnowFor thousands of years, healers have used plants to cure illness. Aspirin, the world's most widely used drug, is based on compounds originally extracted from the bark of a willow tree, and more than a quarter of medicines found on pharmacy shelves contain plant compounds. Now Western medicine, faced with health crises such as AIDS, Alzheimer's disease, and cancer, has begun to look to the healing plants used by indigenous peoples to develop powerful new medicines. Nowhere is the search more promising than in the Amazon, the world's largest tropical forest, home to a quarter of all botanical species on this planet—as well as hundreds of Indian tribes whose medicinal plants have never been studied by Western scientists. In Tales of a Shaman's Apprentice, ethnobotanist Mark J. Plotkin recounts his travels and studies with some of the most powerful Amazonian shamans, who taught him the plant lore their tribes have spent thousands of years gleaning from the rain forest.For more than a decade, Dr. Plotkin raced against time to harvest and record new plants before the rain forests' fragile ecosystems succumb to overdevelopment—and before the Indians abandon their own culture and learning for the seductive appeal of Western material culture. Tales of a Shaman's Apprentice relates nine of the author's quests, taking the reader along on a wild odyssey as he participates in healing rituals; discovers the secret of curare, the lethal arrow poison that kills in minutes; tries the hallucinogenic snuff epena that enables the Indians to speak with their spirit world; and earns the respect and fellowship of the mysterious shamans as he proves that he shares both their endurance and their reverence for the rain forest.

In his most extraordinary book, Oliver Sacks recounts the stories of patients lost in the bizarre, apparently inescapable world of neurological disorders. These are case studies of people who have lost their memories and with them the greater part of their pasts; who are no longer able to recognize people or common objects; whose limbs have become alien; who are afflicted and yet are gifted with uncanny artistic or mathematical talents. In Dr Sacks' splendid and sympathetic telling, each tale is a unique and deeply human study of life struggling against incredible adversity.

Upon its original publication, Plagues and Peoples was an immediate critical and popular success, offering a radically new interpretation of world history as seen through the extraordinary impact--political, demographic, ecological, and psychological--of disease on cultures. From the conquest of Mexico by smallpox as much as by the Spanish, to the bubonic plague in China, to the typhoid epidemic in Europe, the history of disease is the history of humankind. With the identification of AIDS in the early 1980s, another chapter has been added to this chronicle of events, which William McNeill explores in his new introduction to this updated editon.Thought-provoking, well-researched, and compulsively readable, Plagues and Peoples is that rare book that is as fascinating as it is scholarly, as intriguing as it is enlightening. "A brilliantly conceptualized and challenging achievement" (Kirkus Reviews), it is essential reading, offering a new perspective on human history.

The definitive overview of this transformative breathwork.In this long-awaited book, Stanislav Grof and Christina Grof describe their groundbreaking new form of self-exploration and Holotropic Breathwork. Holotropic means “moving toward wholeness,” from the Greek holos (whole) and trepein (moving in the direction of). The breathwork utilizes the remarkable healing and transformative potential of nonordinary states of consciousness. These states engender a rich array of experiences with unique healing potential—reliving childhood memories, infancy, birth and prenatal life, and elements from the historical and archetypal realms of the collective unconscious. Induced by very simple means—a combination of accelerated breathing, evocative music, and bodywork in a safe and supportive setting, Holotropic Breathwork integrates the insights from modern consciousness research, depth psychology, transpersonal psychology, anthropology, Eastern spiritual practices, and mystical traditions. The Grofs’ work with holotropic states of consciousness has introduced revolutionary changes to psychiatry, psychology, and psychotherapy. Written in a clear, easily understandable style, this indispensable book summarizes their remarkable insights.“Stanislav Grof is one of the most important pioneers in the scientific understanding of consciousness. He and his wife, Christina, have contributed both to its intellectual and experiential understanding through their work with Holotropic Breathwork. Their book on this new approach to self-exploration and therapy is a must read.” — Deepak Chopra, author of Reinventing the Body, Resurrecting the How to Create a New You“This fascinating, informative book invites you to open your mind to explore the depths of the psyche and transpersonal dimensions of consciousness. Stanislav and Christina Grof, who pioneered this powerful, innovative approach to therapy and personal growth, offer sound advice, thoroughly grounded in decades of practical experience.” — Frances Vaughan, author of Shadows of the Seeing Through Spiritual Illusions“Take a few rapid, staccato breaths and open this book. You will have a great read, and at the same time maybe discover a new kind of consciousness, just waiting inside of you to be revealed. Stanislav and Christina Grof are modern pioneers of consciousness and this book is their map of the territory. Holotropic Breathwork reveals how the Grofs developed their revolutionary healing techniques, often told through fascinating stories of people being transformed by the breathwork process. The Grofs are at the center of the current psycho-spiritual revolution in the West, and this book is a testament to their role in our collective healing.” — Wes Nisker, author of The Essential Crazy Wisdom and Buddha’s A Practical Guide to Discovering Your Place in the Cosmos“The Grofs offer the first comprehensive text of the theory and practice of their pioneering and integrative model of experiential psychotherapy and self-exploration. This ‘psychology of the future,’ with its extended cartography of the psyche, provides irrefutable evidence that spontaneous episodes of nonordinary states of consciousness have great healing, transformative, and even evolutionary potential for humankind. History will record that Holotropic Breathwork and the certification training and program designed by the Grofs advanced the field of psychotherapy far beyond the contributions of Freud and Jung.” — Angeles Arrien, author of The Four-Fold Walking the Paths of the Warrior, Teacher, Healer, and Visionary“In this remarkable book Stanislav and Christina Grof summarize their pathbreaking discoveries of the past thirty years. They make two significant contributions, one to science, the other to our shared future. The first, by showing that altered states of consciousness have a dimension that is veridical—‘imaginal’ rather than ‘imaginary’—and thereby transcend the outdated but still persistent belief that our experience of the world is limited to information conveyed by our senses. The second, by demonstrating that the altered states achieved inter alia through their holotropic breathwork method reduce aggression and enhance tolerance, compassion, ecological sensitivity, and a sense of planetary citizenship. Since these are the very qualities we urgently need to cope with the global emergency in which we presently find ourselves, their contribution to the future of humankind matches their contribution to the future of psychology.” — Ervin Laszlo, author of The Connectivity Foundations of an Integral Science of Quantum, Cosmos, Life, and Consciousness“Holotropic Breathwork appears to have the potential for facilitating psychological insights and transformations that can be remarkably rapid and deep.” — Roger Walsh, coeditor of Higher Eminent Elders Explore the...

Can we live robustly until our last breath?Do we have to suffer from debilitating conditions and sickness? Is it possible to add more vibrant years to our lives? In the #1 New York Times bestselling The End of Illness , Dr. David Agus tackles these fundamental questions and dismantles misperceptions about what “health” really means. Presenting an eye-opening picture of the human body and all the ways it works—and fails—Dr. Agus shows us how a new perspective on our individual health will allow us to achieve a long, vigorous life.Offering insights and access to powerful new technologies that promise to transform medicine, Dr. Agus emphasizes his belief that there is no “right” answer, no master guide that is “one size fits all.” Each one of us must get to know our bodies in uniquely personal ways, and he shows us exactly how to do that. A bold call for all of us to become our own personal health advocates, The End of Illness is a moving departure from orthodox thinking.

Upon becoming a new mother, Eula Biss addresses a chronic condition of fear--fear of the government, the medical establishment, and what is in your child's air, food, mattress, medicine, and vaccines. She finds that you cannot immunize your child, or yourself, from the world.In this bold, fascinating book, Biss investigates the metaphors and myths surrounding our conception of immunity and its implications for the individual and the social body. As she hears more and more fears about vaccines, Biss researches what they mean for her own child, her immediate community, America, and the world, both historically and in the present moment. She extends a conversation with other mothers to meditations on Voltaire's Candide, Bram Stoker's Dracula, Rachel Carson's Silent Spring, Susan Sontag's AIDS and Its Metaphors, and beyond.On Immunity is a moving account of how we are all interconnected-our bodies and our fates.

New York Times bestselling author Dr. Neal Barnard reveals the shocking truth about cheese-the dangerous addiction that is harming your health-and presents a radical program to lose weight and feel great.We've been told that dairy does a body good, but the truth is that cheese can be dangerous. Loaded with calories, fat, and cholesterol, cheese can make you gain weight and leads to a host of health problems like high blood pressure and arthritis. Worse, it contains mild opiates that make it additive, triggering the same brain receptors as heroin and morphine.In The Cheese Trap , Dr. Neal Barnard presents a comprehensive program to help readers break free of their cheese addiction so they can lose weight, boost energy, and improve their overall health. This easy-to-follow diet features a treasury of healthy recipes that will tame even the toughest cravings-from pizza, to lasagna, to ice cream and cheesecake.

A Science Friday pick for book of the year, 2019One of America's top doctors reveals how AI will empower physicians and revolutionize patient care Medicine has become inhuman, to disastrous effect. The doctor-patient relationship--the heart of medicine--is doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality. By freeing physicians from the tasks that interfere with human connection, AI will create space for the real healing that takes place between a doctor who can listen and a patient who needs to be heard.Innovative, provocative, and hopeful, Deep Medicine shows us how the awesome power of AI can make medicine better, for all the humans involved.

A magnificently reported and soulfully crafted exploration of the human immune system–the key to health and wellness, life and death. An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

#1 NEW YORK TIMES BESTSELLER • A groundbreaking manifesto on living better and longer that challenges the conventional medical thinking on aging and reveals a new approach to preventing chronic disease and extending long-term health, from a visionary physician and leading longevity expert “One of the most important books you’ll ever read.”—Steven D. Levitt, New York Times bestselling author of Freakonomics Wouldn’t you like to live longer? And better? In this operating manual for longevity, Dr. Peter Attia draws on the latest science to deliver innovative nutritional interventions, techniques for optimizing exercise and sleep, and tools for addressing emotional and mental health. For all its successes, mainstream medicine has failed to make much progress against the diseases of aging that kill most people: heart disease, cancer, Alzheimer’s disease, and type 2 diabetes. Too often, it intervenes with treatments too late to help, prolonging lifespan at the expense of healthspan, or quality of life. Dr. Attia believes we must replace this outdated framework with a personalized, proactive strategy for longevity, one where we take action now, rather than waiting. This is not “biohacking,” it’s science: a well-founded strategic and tactical approach to extending lifespan while also improving our physical, cognitive, and emotional health. Dr. Attia’s aim is less to tell you what to do and more to help you learn how to think about long-term health, in order to create the best plan for you as an individual. In Outlive, readers will discover: • Why the cholesterol test at your annual physical doesn’t tell you enough about your actual risk of dying from a heart attack.• That you may already suffer from an extremely common yet underdiagnosed liver condition that could be a precursor to the chronic diseases of aging.• Why exercise is the most potent pro-longevity “drug”—and how to begin training for the “Centenarian Decathlon.”• Why you should forget about diets, and focus instead on nutritional biochemistry, using technology and data to personalize your eating pattern.• Why striving for physical health and longevity, but ignoring emotional health, could be the ultimate curse of all. Aging and longevity are far more malleable than we think; our fate is not set in stone. With the right roadmap, you can plot a different path for your life, one that lets you outlive your genes to make each decade better than the one before.

Molecular Biology of the Cell is the classic in-dept text reference in cell biology. By extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and create a coherent framework through which non-expert readers may approach the subject. Written in clear and concise language, and beautifully illustrated, the book is enjoyable to read, and it provides a clear sense of the excitement of modern biology. Molecular Biology of the Cell sets forth the current understanding of cell biology (completely updated as of Autumn 2001), and it explores the intriguing implications and possibilities of the great deal that remains unknown. The hallmark features of previous editions continue in the Fourth Edition. The book is designed with a clean and open, single-column layout. The art program maintains a completely consistent format and style, and includes over 1,600 photographs, electron micrographs, and original drawings by the authors. Clear and concise concept headings introduce each section. Every chapter contains extensive references. Most important, every chapter has been subjected to a rigorous, collaborative revision process where, in addition to incorporating comments from expert reviewers, each co-author reads and reviews the other authors' prose. The result is a truly integrated work with a single authorial voice. Features : - Places the latest hot topics sensibly in context - including genomics, protein structure, array technology, stem cells and genetics diseases. - Incorporates and emphasises new genomic data. - All of molecular biology is brought together into one section (chapters 4-7) covering classically defined molecular biology and molecular genetics. - Two chapters deal exclusively with methods and contain information on the latest tools and techniques. - New chapters on "Pathogens, Infection, and Innate Immunity". - Cell Biology Interactive CD-ROM is packaged with every copy of the book. - Contains over 1,600 illustrations, electron micrographs and photographs, of which over 1,000 are originally conceived by the authors.

Now in a third edition, Robert M. Sapolsky's acclaimed and successful Why Zebras Don't Get Ulcers features new chapters on how stress affects sleep and addiction, as well as new insights into anxiety and personality disorder and the impact of spirituality on managing stress.As Sapolsky explains, most of us do not lie awake at night worrying about whether we have leprosy or malaria. Instead, the diseases we fear—and the ones that plague us now—are illnesses brought on by the slow accumulation of damage, such as heart disease and cancer. When we worry or experience stress, our body turns on the same physiological responses that an animal's does, but we do not resolve conflict in the same way—through fighting or fleeing. Over time, this activation of a stress response makes us sick.

Être rationnel, ce n'est pas se couper de ses émotions. Le cerveau qui pense, qui calcule, qui décide n'est pas autre chose que celui qui rit, qui pleure, qui aime, qui éprouve du plaisir et du déplaisir. Le coeur a ses raisons que la raison... est loin d'ignorer. Contre le vieux dualisme cartésien et contre tous ceux qui voudraient réduire le fonctionnement de l'esprit humain à de froids calculs dignes d'un super ordinateur, c'est en tout cas ce que révèlent les acquis récents de la neurologie : l'absence d'émotions et de sentiments empêche d'être vraiment rationnel. Antonio R. Damasio est professeur de psychologie, de neurosciences et de neurologie. Il est directeur de l'Institut pour l'étude neurologique de l'émotion, de la décision et de la créativité, à l'Université de Californie du Sud. Il est également l'auteur de Spinoza avait raison et du Sentiment même de soi.

From Chocolate to Morphine is the definitive guide to drugs and drug use from one of America’s most respected and best-known doctors. This enormously popular book — the best and most authoritative resource for unbiased information about how drugs affect the mind and the body — covers a wide range of available substances, from coffee to marijuana, antihistamines to psychedelics, steroids to smart drugs, and discusses likely effects, precautions, and alternatives. Now expanded and updated to cover such drugs as oxycontin, Ecstasy, Prozac, and ephedra and to address numerous ongoing issues, including the United States’ war on drugs, marijuana for therapeutic use, the overuse of drugs for children diagnosed with ADHD, and more, From Chocolate to Morphine is an invaluable resource.

A world-famous ethnobotanist scours the planet in search of new natural cures, unveiling the healing power in snake venom, leech saliva, rain-forest frogs, and other natural sources. Reprint.

In 1918 the Great Flu Epidemic killed an estimated 40 million people virtually overnight. If such a plague returned today, taking a comparable percentage of the U.S. population with it, 1.5 million Americans would die.The fascinating, true story of the world's deadliest disease.In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out.Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for "The New York Times," unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.

A highly infectious, deadly virus from the central African rain forest suddenly appears in the suburbs of Washington, D.C. There is no cure. In a few days 90 percent of its victims are dead. A secret military SWAT team of soldiers and scientists is mobilized to stop the outbreak of this exotic "hot" virus. The Hot Zone tells this dramatic story, giving a hair-raising account of the appearance of rare and lethal viruses and their "crashes" into the human race. Shocking, frightening, and impossible to ignore, The Hot Zone proves that truth really is scarier than fiction.

This is the book that has given thousands of sufferers new hope--a gentle, effective way to find real relief from back pain, without painkillers, without surgery, without spending days on end in bed. Dr. John Sarno 's revolutionary approach to back pain is based on his discovery that tension is the underlying cause of most back problems--leading to an often unrecognized condition called Tension Mytosis Syndrome. In this book--the first to explain the psychophysiology, manifestations, and treatment of TMS--you'll find clear steps, sensible advice, and simple illustrations to help you find relief, prevent future pain...and live life fully once again.

From the best-selling author of SPONTANEOUS HEALING, a brilliantly conceived, safe and effective eight-week programme for improving and maintaining health. Dr Weil first explains, then shows how, week by week, gradual changes can lead to long-term benefits such as greater vitality, weight loss and a body which heals itself. Incorporating alternative medicines and treatments, he provides specific and detailed information on diet (with 50 recipes), exercise, stress reduction techniques, and vitamins and supplements. He also customizes programmes for a dozen categories, such as pregnant women, people at risk of cancer, overweight people, and senior citizens. Building on the breakthrough thinking of SPONTANEOUS HEALING, Dr Weil provides an invaluable means to maintain health and lessen the need for medical intervention.

In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading, at that point the largest gain in stock market history. Coming at a time of economic recession and declining technological competitiveness in the United States, the event provoked banner headlines and ignited a period of speculative frenzy over biotechnology as a revolutionary means for creating new and better kinds of pharmaceuticals, untold profit, and a possible solution to national economic malaise. Drawing from an unparalleled collection of interviews with early biotech players, Sally Smith Hughes offers the first book-length history of this pioneering company, depicting Genentech’s improbable creation, precarious youth, and ascent to immense prosperity. Hughes provides intimate portraits of the people significant to Genentech’s science and business, including cofounders Herbert Boyer and Robert Swanson, and in doing so sheds new light on how personality affects the growth of science. By placing Genentech’s founders, followers, opponents, victims, and beneficiaries in context, Hughes also demonstrates how science interacts with commercial and legal interests and university research, and with government regulation, venture capital, and commercial profits. Integrating the scientific, the corporate, the contextual, and the personal, Genentech tells the story of biotechnology as it is not often told, as a risky and improbable entrepreneurial venture that had to overcome a number of powerful forces working against it.

Have you ever seen something that wasn’t really there? Heard someone call your name in an empty house? Sensed someone following you and turned around to find nothing? Hallucinations don’t belong wholly to the insane. Much more commonly, they are linked to sensory deprivation, intoxication, illness, or injury. People with migraines may see shimmering arcs of light or tiny, Lilliputian figures of animals and people. People with failing eyesight, paradoxically, may become immersed in a hallucinatory visual world. Hallucinations can be brought on by a simple fever or even the act of waking or falling asleep, when people have visions ranging from luminous blobs of color to beautifully detailed faces or terrifying ogres. Those who are bereaved may receive comforting “visits” from the departed. In some conditions, hallucinations can lead to religious epiphanies or even the feeling of leaving one’s own body. Humans have always sought such life-changing visions, and for thousands of years have used hallucinogenic compounds to achieve them. As a young doctor in California in the 1960s, Oliver Sacks had both a personal and a professional interest in psychedelics. These, along with his early migraine experiences, launched a lifelong investigation into the varieties of hallucinatory experience. Here, with his usual elegance, curiosity, and compassion, Dr. Sacks weaves together stories of his patients and of his own mind-altering experiences to illuminate what hallucinations tell us about the organization and structure of our brains, how they have influenced every culture’s folklore and art, and why the potential for hallucination is present in us all, a vital part of the human condition.

Just before dawn on a Sunday morning, three teenage boys go surfing. While driving home exhausted, the boys are involved in a fatal car accident on a deserted road. Two of the boys are wearing seat belts; one goes through the windshield. The doctors declare him brain-dead shortly after arriving at the hospital, but his heart is still beating.The Heart takes place over the twenty-four hours surrounding the resulting heart transplant, as life is taken from a young man and given to a woman close to death. In gorgeous, ruminative prose, it examines the deepest feelings of everyone involved as they navigate decisions of life and death.As stylistically audacious as it is emotionally explosive, The Heart mesmerized readers in France, where it has been hailed as the breakthrough work of a new literary star. With the precision of a surgeon and the language of a poet, de Kerangal has made a major contribution to both medicine and literature with an epic tale of grief, hope, and survival.

Ai rồi cũng chết! là một tuyệt phẩm đánh động lòng người được viết nên bởi bác sĩ kiêm tác giả best-seller Atul Gawande. Cuốn sách không chỉ có khả năng lay chuyển ngành y học hiện đại, mà nó còn sẽ giúp làm biến đổi hoàn toàn cuộc sống của muôn người - bao gồm chính bạn!Ngành y học thế giới đã có nhiều bước phát triển vượt bậc trong những năm giảm thiểu tỉ lệ tử vong trẻ sơ sinh, nâng cao tỉ lệ sống sót sau chấn thương, chữa trị và kiểm soát được nhiều loại bệnh tật - kể cả nhiều căn bệnh từng được xem là không có thuốc chữa trong quá khứ. Nhưng dù có bành trướng hùng mạnh đến đâu, y học vẫn muôn đời bất lực trước quy luật sinh-lão-bệnh-tử bất biến của con ngườ Mỗi khi con người phải đối diện với Tuổi Già và Cái Chết, những công cụ y học vốn dĩ quyền năng bỗng chốc phản bội lại chính lý tưởng cứu nhân độ thế mà chúng đang phục vụ.Bằng những công trình nghiên cứu khoa học giá trị và những câu chuyện sống động từ các bệnh nhân và người thân của chính mình, bác sĩ Gawande bóc trần cho chúng ta thấy những hệ lụy và nỗi đau mà con người phải gánh chịu bởi nghịch lý trên. Viện dưỡng lão vốn dĩ được lập ra với mục đích ban đầu tốt đẹp là giúp cho người cao tuổi có một cuộc sống hạnh phúc và viên mãn bất chấp tuổi già, nhưng nhiều nhà dưỡng lão ngày nay bị biến tướng thành những tòa nhà khép kín không khác gì nhà tù, nơi mà người già không được phép ăn những món ăn họ thích và không được phép làm những gì mình muốn. Nhiều bác sĩ được đào tạo xuất sắc về mặt chuyên môn, nhưng lại không biết cách làm thế nào để nói cho bệnh nhân biết sự thật về bệnh tình của họ; thay vào đó, bác sĩ lại vin vào những hy vọng hão huyền về khả năng cứu sống người bệnh của y học và đề xuất cho bệnh nhân hàng loạt biện pháp chữa trị để nuôi những hy vọng hão đó. Rốt cuộc, hành động này chỉ khiến cho người bệnh và cả thân nhân của họ thêm hao mòn khổ sở chứ không hề mang lại ích lợi gì cho họ cả về mặt thể xác lẫn tinh thần.Trong những cuốn sách của mình, bác sĩ phẫu thuật Atul Gawande đã dùng ngòi bút mạnh mẽ không chút sợ hãi của mình tiết lộ cho chúng ta biết sự thật đằng sau ngành y cũng như những cuộc chiến mà các thầy thuốc như ông phải đối mặt và tranh đấu vượt qua. Lần này, với tác phẩm Ai rồi cũng chết!, ông phơi bày cho chúng ta thấy những giới hạn và nhược điểm của ngành y - trong cả chuyên môn của ông lẫn những chuyên ngành khác - khi cuộc sống con người bị đe dọa bởi sự lão hóa và cái chết. Qua đó, ông cũng đồng thời khám phá ra rằng mọi chuyện đều có cách giải quyết, rằng chúng ta hoàn toàn có thể làm khác đi, để mang lại cuộc sống tốt đẹp hơn cho mọi người cũng như cho chính bản thân chúng ta.Để khai phá ngọn nguồn mọi vấn đề cũng như giải pháp, bác sĩ Gawande đã theo chân một nữ y tá làm công việc chăm sóc bệnh nhân tại gia, phỏng vấn nhiều người trong giới bác sĩ lão khoa và sinh hoạt cùng họ, và tiếp xúc với những nhà quản lý viện dưỡng lão có tư tưởng cấp tiến và nhân văn. Ông tìm thấy những con người biết cách nói lên sự thật và chứng minh cho cả thế giới thấy, rằng mỗi người chúng ta đều có thể và có quyền mưu cầu cho mình một cuộc sống tốt đẹp và hạnh phúc bất chấp tuổi già sức yếu mà không phải hy sinh những giá trị sống mà chúng ta yêu quý hoặc tôn thờ.Với cách kể chuyện chân thực, sống động, mê hoặc và đánh động lòng người của tác giả, quyển sách Ai rồi cũng chết!khẳng định với chúng ta rằ Mỗi con người sinh ra không phải chỉ để ăn, ngủ hay tồn tại qua ngày, mà chính là để được sống một cuộc sống đúng nghĩa; rằng mục đích cuối cùng của y học không phải để kéo dài sự tồn tại vô nghĩa của con người, mà chính là để giúp chúng ta có một cuộc sống mãi mãi đong đầy hạnh phúc - cho đến tận phút lâm chung!

In fascinating detail, Sam Quinones chronicles how, over the past 15 years, enterprising sugar cane farmers in a small county on the west coast of Mexico created a unique distribution system that brought black tar heroin—the cheapest, most addictive form of the opiate, 2 to 3 times purer than its white powder cousin—to the veins of people across the United States. Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

Jon Ronson meets David Grann in this fascinating, wildly entertaining adventure and travel story about how culture can make us go totally insaneThe Geography of Madness is an investigation of "culture-bound" syndromes, which are far stranger than they sound. Why is it, for example, that some men believe, against all reason, that vandals stole their penises, even though they're in good physical shape? In The Geography of Madness, acclaimed magazine writer Frank Bures travels around the world to trace culture-bound syndromes to their sources—and in the process, tells a remarkable story about the strange things all of us believe.Book Club Discussion Questions: For the paperback edition, a list of book club discussion questions is also being issued. If you’d like to add the The Geography of Madness to your group’s reading list, here are several conversation starters:1) One main themes of The Geography of Madness is that stories (about the world, about our lives, about our bodies) are contagious. Can you think of a story, or an experience, that changed what you believed was possible?2) Do you believe the brain and the mind are the same thing? If not, what is the difference? 3) The stories in The Geography of Madness raise the question of free will: How much do you choose the life you live? How much do you learn (or catch) you life choices from those around you? 4) Have you ever found yourself immersed in a situation where you did not know the rules? What was that like?5) In The Geography of Madness, the author argues that our mindset and our expectations have biological consequences. Does that resemble your experience? If so, how?6) Try to imagine living in a world where it was possible to have your genitals stolen, either by magic or by ghosts. How would you protect yourself?7) In The Geography of Madness, the author argues that a strong sense of self—of your story— can help to activate your endogenous (internal) healing systems and vice versa. Do you remember a time when a stressful or difficult period seemed to be followed by a health problem or sickness? 8) In The Geography of Madness, did anyone’s genital actually disappear? If not, what happened? Does it matter?9) Is there a belief that everyone around you holds, but that you don’t share? How did you come to doubt this?10) The Handbook of Depression points to a genetic marker associated with greater vulnerability to depression. Yet this link only holds true in Western cultures. Why would that be?11) Have you ever had a health problem you were afraid to talk about, or that others didn’t believe in?12) In The Geography of Madness, the author argues that cultural syndromes are “real” syndromes, but that their causes might not lie where we think they do. Do you think they are “real” or “imaginary”? 13) Over the last few years, gluten intolerance has been rising. This rise occurs at a time of increasing anxiety about the relationship between food, health and identity. What’s changed: our bodies or our culture?14) After reading The Geography of Madness, how would you describe what culture is?15) How much does a your culture create you? How much do you create your culture?16) Have you ever had a cultural syndrome?

This riveting narrative explores the world of placebos, hypnosis, false memories, and neurology to reveal the groundbreaking science of our suggestible minds. Could the secrets to personal health lie within our own brains? Journalist Erik Vance explores the surprising ways our expectations and beliefs influence our bodily responses to pain, disease, and everyday events. Drawing on centuries of research and interviews with leading experts in the field, Vance takes us on a fascinating adventure from Harvard’s research labs to a witch doctor’s office in Catemaco, Mexico, to an alternative medicine school near Beijing (often called “China’s Hogwarts”). Vance’s firsthand dispatches will change the way you think—and feel. Continuing the success of National Geographic’s brain books and rounding out our pop science category, this book shows how expectations, beliefs, and self-deception can actively change our bodies and minds. Vance builds a case for our “internal pharmacy”—the very real chemical reactions our brains produce when we think we are experiencing pain or healing, actual or perceived. Supporting this idea is centuries of placebo research in a range of forms, from sugar pills to shock waves; studies of alternative medicine techniques heralded and condemned in different parts of the world (think crystals and chakras); and most recently, major advances in brain mapping technology. Thanks to this technology, we're learning how we might leverage our suggestibility (or lack thereof) for personalized medicine, and Vance brings us to the front lines of such study.From the Hardcover edition.

The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life.Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free).THE TELOMERE EFFECT reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. THE TELOMERE EFFECT will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

Western medicine has not been particularly successful at getting people relief from conditions like depression, chronic pain, migraine headaches, addiction, and PTSD. Dr. Tafur helps us to understand why.I have watched people spend years in frustration and thousands of dollars consulting an army of specialists, without getting real relief from their problem. Because these and others are diseases deeply connected with the state of our emotional bodies. Too often, the Western medical approach fails to address the emotional dimension of illness. This is where traditional plant medicines, with their ability to alter consciousness and open channels of communication to our emotions, offer so much promise.The stories shared here demonstrate the astonishing-mystical, colorful, metaphysical-effects of ayahuasca and Traditional Amazonian Plant Medicine. Follow Dr. Tafur through the Amazon jungle as he develops a breakthrough understanding of how psychoactive plants interact with the complex network that connects our minds and hearts to our physical anatomy. What Dr. Tafur presents here is nothing short of a paradigm shift for modern medicine, where sacred plants, used properly in ceremony, take their place as important tools in the doctor's medicine chest, offering the missing elements of emotional and spiritual healing that have eluded us for so long.For more information about The Fellowship of The River, please visit https: //drjoetafur.com/the-fellowship-of-the-...

In the dying months of World War I, Spanish flu suddenly overwhelmed the world, killing between 50 and 100 million people.German soldiers termed it Blitzkatarrh, British soldiers called it Flanders Grippe, but globally the pandemic gained the notorious title of ‘Spanish Flu’.Nowhere escaped this common in Britain, 250,000 people died, in the United States it was 750,000, five times its total military fatalities in the war, while European deaths reached over two million. The numbers are staggering. And yet at the time, news of the danger was suppressed for fear of impacting war-time morale. Even today these figures are shocking to many – the war still hiding this terrifying menace in its shadow.And behind the numbers are human lives, stories of those who suffered and fought it – in the hospitals and laboratories. Catharine Arnold traces the course of the disease, its origins and progress, across the globe via these remarkable people. Some are well known to us, like British Prime Minister David Lloyd George, US President Woodrow Wilson, and writers Robert Graves and Vera Brittain, but many more are unknown. They are the doughboys from the US, gold miners in South Africa, schoolgirls in Great Britain and many others. Published 100 years after the most devastating pandemic in world history, Pandemic 1918 uses previously unpublished records, memoirs, diaries and government publications to uncover the human story of 1918.

One of the world's top behavioural geneticists argues that we need a radical rethink about what makes us who we are The blueprint for our individuality lies in the 1% of DNA that differs between people. Our intellectual capacity, our introversion or extraversion, our vulnerability to mental illness, even whether we are a morning person - all of these aspects of our personality are profoundly shaped by our inherited DNA differences. In Blueprint, Robert Plomin, a pioneer in the field of behavioural genetics, draws on a lifetime's worth of research to make the case that DNA is the most important factor shaping who we are. Our families, schools and the environment around us are important, but they are not as influential as our genes. This is why, he argues, teachers and parents should accept children for who they are, rather than trying to mould them in certain directions. Even the environments we choose and the signal events that impact our lives, from divorce to addiction, are influenced by our genetic predispositions. Now, thanks to the DNA revolution, it is becoming possible to predict who we will become, at birth, from our DNA alone. As Plomin shows us, these developments have sweeping implications for how we think about parenting, education, and social mobility. A game-changing book by a leader in the field, Blueprint shows how the DNA present in the single cell with which we all begin our lives can impact our behaviour as adults.

NEW YORK TIMES BESTSELLER • A must-read owner’s manual for every body. Take a head-to-toe tour of the marvel that is the human body in this “delightful, anecdote-propelled read” ( The Boston Globe ) from the author of A Short History of Nearly Everything . With a new Afterword.“You will marvel at the brilliance and vast weirdness of your design." — The Washington Post Bill Bryson once again proves himself to be an incomparable companion as he guides us through the human body—how it functions, its remarkable ability to heal itself, and (unfortunately) the ways it can fail. Full of extraordinary facts (your body made a million red blood cells since you started reading this) and irresistible Brysonesque anecdotes, The Body will lead you to a deeper understanding of the miracle that is life in general and you in particular.As Bill Bryson writes, “We pass our existence within this wobble of flesh and yet take it almost entirely for granted.” The Body will cure that indifference with generous doses of wondrous, compulsively readable facts and information. As addictive as it is comprehensive, this is Bryson at his very best.

When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

A gorgeously illustrated deep dive into the immune system that will forever change how you think about your body, from the creator of the popular science YouTube channel Kurzgesagt—In a NutshellYou wake up and feel a tickle in your throat. Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door.So what, exactly, is your immune system?Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body.Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defenses, how viruses work, and what goes on in your wounds when you cut yourself.Enlivened by engaging graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.

Longlisted for the FT/McKinsey Business Book of the Year Award The authoritative account of the race to produce the vaccines that are saving us all, from the #1 New York Times bestselling author of The Man Who Solved the MarketFew were ready when a mysterious respiratory illness emerged in Wuhan, China in January 2020. Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response. It was up to a small group of unlikely and untested scientists and executives to save civilization. A French businessman dismissed by many as a fabulist. A Turkish immigrant with little virus experience. A quirky Midwesterner obsessed with insect cells. A Boston scientist employing questionable techniques. A British scientist despised by his peers. Far from the limelight, each had spent years developing innovative vaccine approaches. Their work was met with skepticism and scorn. By 2020, these individuals had little proof of progress. Yet they and their colleagues wanted to be the ones to stop the virus holding the world hostage. They scrambled to turn their life’s work into life-saving vaccines in a matter of months, each gunning to make the big breakthrough—and to beat each other for the glory that a vaccine guaranteed. A #1 New York Times bestselling author and award-winning Wall Street Journal investigative journalist, Zuckerman takes us inside the top-secret laboratories, corporate clashes, and high-stakes government negotiations that led to effective shots. Deeply reported and endlessly gripping, this is a dazzling, blow-by-blow chronicle of the most consequential scientific breakthrough of our time. It’s a story of courage, genius, and heroism. It’s also a tale of heated rivalries, unbridled ambitions, crippling insecurities, and unexpected drama. A Shot to Save the World is the story of how science saved the world.

Neuroscientist V.S. Ramachandran is internationally renowned for uncovering answers to the deep and quirky questions of human nature that few scientists have dared to address. His bold insights about the brain are matched only by the stunning simplicity of his experiments -- using such low-tech tools as cotton swabs, glasses of water and dime-store mirrors. In Phantoms in the Brain, Dr. Ramachandran recounts how his work with patients who have bizarre neurological disorders has shed new light on the deep architecture of the brain, and what these findings tell us about who we are, how we construct our body image, why we laugh or become depressed, why we may believe in God, how we make decisions, deceive ourselves and dream, perhaps even why we're so clever at philosophy, music and art. Some of his most notable cases:A woman paralyzed on the left side of her body who believes she is lifting a tray of drinks with both hands offers a unique opportunity to test Freud's theory of denial.A man who insists he is talking with God challenges us to ask: Could we be "wired" for religious experience?A woman who hallucinates cartoon characters illustrates how, in a sense, we are all hallucinating, all the time.Dr. Ramachandran's inspired medical detective work pushes the boundaries of medicine's last great frontier -- the human mind -- yielding new and provocative insights into the "big questions" about consciousness and the self.

On its initial publication, Forgive and Remember emerged as the definitive study of the training and lives of young surgeons. Now with an extensive new preface, epilogue, and appendix by the author, reflecting on the changes that have taken place since the book's original publication, this updated second edition of Charles L. Bosk's classic study is as timely as ever.

In this nationally bestselling, compulsively readable account of what makes brain science a vital component of people's quest to know themselves, acclaimed science writer Steven Johnson subjects his own brain to a battery of tests to find out what's really going on inside. He asks:

Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research.Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing—atom by atom—both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS.You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.

Neither a just say no treatise nor a how-to manual, this easy-to-read handbook is based on the conviction that the well-informed make better decisions. It provides information on how drugs enter the body, how they manipulate the brain, their short- & long-term effects, the high they produce & the circumstances in which they can be deadly. psychological & pharmacological research on drugs. Whether the reader is a student confronted by drugs for the first time, an accountant reaching for another cup of coffee, or a health educator, this book aims to provide a clear understanding of how drugs work & the consequences of their use.

Cholera was the classic epidemic disease of the nineteenth century, as the plague had been for the fourteenth. Its defeat was a reflection not only of progress in medical knowledge but of enduring changes in American social thought. Rosenberg has focused his study on New York City, the most highly developed center of this new society. Carefully documented, full of descriptive detail, yet written with an urgent sense of the drama of the epidemic years, this narrative is as absorbing for general audiences as it is for the medical historian. In a new Afterword, Rosenberg discusses changes in historical method and concerns since the original publication of The Cholera Years ."A major work of interpretation of medical and social thought . . . this volume is also to be commended for its skillful, absorbing presentation of the background and the effects of this dread disease."—I.B. Cohen, New York Times" The Cholera Years is a masterful analysis of the moral and social interest attached to epidemic disease, providing generally applicable insights into how the connections between social change, changes in knowledge and changes in technical practice may be conceived."—Steven Shapin, Times Literary Supplement"In a way that is all too rarely done, Rosenberg has skillfully interwoven medical, social, and intellectual history to show how medicine and society interacted and changed during the 19th century. The history of medicine here takes its rightful place in the tapestry of human history."—John B. Blake, Science

A fascinating account of vaccination's miraculous, inflammatory past and its uncertain future.In 1796, as smallpox ravaged Europe, Edward Jenner injected a child with a benign version of the disease, then exposed the child to the deadly virus itself. The boy proved resistant to smallpox, and Jenner's risky experiment produced the earliest vaccination. In this deftly written account, journalist Arthur Allen reveals a history of vaccination that is both illuminated with hope and shrouded by controversy—from Jenner's discovery to Pasteur's vaccines for rabies and cholera, to those that safeguarded the children of the twentieth century, and finally to the tumult currently surrounding vaccination.Faced with threats from anthrax to AIDS, we are a vulnerable population and can no longer depend on vaccines; numerous studies have linked childhood vaccination with various neurological disorders, and our pharmaceutical companies are more attracted to the profits of treatment than to the prevention of disease. With narrative grace and investigative journalism, Allen explores our shifting understanding of vaccination since its creation. 16 pages of illustrations.

Francis Crick, who died at the age of eighty-eight in 2004, will be bracketed with Galileo, Darwin, and Einstein as one of the great scientists of all time. Between 1953 and 1966 he made and led a revolution in biology by discovering, quite literally, the secret of life: the digital cipher at the heart of heredity that distinguishes living from non-living things -- the genetic code. His own discoveries -- though he always worked with one other partner and did much of his thinking in conversation -- include not only the double helix but the whole mechanism of protein synthesis, the three-letter nature of the code, and much of the code itself. Matt Ridley's biography traces Crick's life from middle-class mediocrity in the English Midlands, through a lackluster education and six years designing magnetic mines for the Royal Navy, to his leap into biology at the age of thirty-one. While at Cambridge, he suddenly began to display the unique visual imagination and intense tenacity of thought that would allow him to see the solutions to several great scientific conundrums -- and to see them long before most biologists had even conceived of the problems. Having set out to determine what makes living creatures alive and having succeeded, he immigrated at age sixty to California and turned his attention to the second question that had fascinated him since his youth: What makes conscious creatures conscious? Time ran out before he could find the answer.

To these seven paradoxical tales of neurological disorder and creativity, Oliver Sacks brings the profound compassion and ceaseless curiosity that made "Awakenings" and "The Man Who Mistook His Wife for a Hat" international bestsellers. He transports us into the uncanny worlds of his subjects, including an artist who loses his ability to see (or even imagine) color; a surgeon who performs delicate operations in spite of the compulsive tics and outbursts of Tourette's syndrome; and an autistic professor who holds a Ph.D. in animal science but is so bewildered by the complexity of human emotion that she feels "like an anthropologist on Mars."Through these extraordinary people, Sacks explores what it is to feel, to sense, to remember - to be, ultimately, a coherent self in the world.

With uncommon humanity, candor, wit, and erudition, award-winning author Andrew Solomon takes the reader on a journey of incomparable range and resonance into the most pervasive of family secrets. His contribution to our understanding not only of mental illness but also of the human condition is truly stunning. The Noonday Demon examines depression in personal, cultural, and scientific terms. Drawing on his own struggles with the illness and interviews with fellow sufferers, doctors and scientists, policymakers and politicians, drug designers and philosophers, Solomon reveals the subtle complexities and sheer agony of the disease. He confronts the challenge of defining the illness and describes the vast range of available medications, the efficacy of alternative treatments, and the impact the malady has had on various demographic populations around the world and throughout history. He also explores the thorny patch of moral and ethical questions posed by emerging biological explanations for mental illness. The depth of human experience Solomon chronicles, the range of his intelligence, and his boundless curiosity and compassion will change the reader's view of the world.

I spent five years of my life being treated for cancer, but since then I've spent fifteen years being treated for nothing other than looking different from everyone else. It was the pain from that, from feeling ugly, that I always viewed as the great tragedy of my life. The fact that I had cancer seemed minor in comparison.At age nine, Lucy Grealy was diagnosed with a potentially terminal cancer. When she returned to school with a third of her jaw removed, she faced the cruel taunts of classmates. In this strikingly candid memoir, Grealy tells her story of great suffering and remarkable strength without sentimentality and with considerable wit. Vividly portraying the pain of peer rejection and the guilty pleasures of wanting to be special, Grealy captures with unique insight what it is like as a child and young adult to be torn between two warring impulses: to feel that more than anything else we want to be loved for who we are, while wishing desperately and secretly to be perfect.

Jill Taylor was a 37-year-old Harvard-trained brain scientist when a blood vessel exploded in her brain. Through the eyes of a curious scientist, she watched her mind deteriorate whereby she could not walk, talk, read, write, or recall any of her life. Because of her understanding of the brain, her respect for the cells in her body, and an amazing mother, Jill completely recovered. In My Stroke of Insight, she shares her recommendations for recovery and the insight she gained into the unique functions of the two halves of her brain. When she lost the skills of her left brain, her consciousness shifted away from normal reality where she felt "at one with the universe." Taylor helps others not only rebuild their brains from trauma, but helps those of us with normal brains better understand how we can consciously influence the neural circuitry underlying what we think, how we feel and how we react to life's circumstances.

An unforgettable, illuminating story of how men live and how they survive, from the acclaimed New York Times bestselling author of Cutting for Stone.When Abraham Verghese, a physician whose marriage is unraveling, relocates to El Paso, Texas, he hopes to make a fresh start as a staff member at the county hospital. There he meets David Smith, a medical student recovering from drug addiction, and the two men begin a tennis ritual that allows them to shed their inhibitions and find security in the sport they love and with each other. This friendship between doctor and intern grows increasingly rich and complex, more intimate than two men usually allow. Just when it seems nothing can go wrong, the dark beast from David’s past emerges once again—and almost everything Verghese has come to trust and believe in is threatened as David spirals out of control.

A pioneering and revolutionary book that lays the foundation for a radical new psychology, based on an expanded cartography of the human unconsciousness. Famous for his lifelong research into psychedelic drugs, Dr. Grof constructs a comprehensive and helpful framework out of the bewildering welter of experiences triggered by LSD in patients and research subjects. Current research into the brain and ways of expanding consciousness give this seminal book, first published in 1979, new importance for the light it throws on many fundamental, but hitherto mysterious, human potentialities. Grof's theory of the human psyche transcends the personal and opens ways to a greater understanding of our inner selves.

Anthrax. Smallpox. Incurable and horrifying Ebola-related fevers. For two decades, while a fearful world prepared for nuclear winter, an elite team of Russian bioweaponeers began to till a new killing field: a bleak tract sown with powerful seeds of mass destruction—by doctors who had committed themselves to creating a biological Armageddon. Biohazard is the never-before-told story of Russia’s darkest, deadliest, and most closely guarded Cold War secret. No one knows more about Russia’s astounding experiments with biowarfare than Ken Alibek. Now the mastermind behind Russia’s germ warfare effort reveals two decades of shocking breakthroughs . . . how Moscow’s leading scientists actually reengineered hazardous microbes to make them even more virulent . . . the secrets behind the discovery of an invisible, untraceable new class of biological agents just right for use in political assassinations . . . the startling story behind Russia’s attempt to turn a sample of the AIDS virus into the ultimate bioweapon. And in a chilling work of real-world intrigue, Biohazard offers us all a rare glimpse into a shadowy scientific underworld where doctors manufacture mass destruction, where witnesses to errors are silenced forever, and where ground zero is closer than we ever dared believe.

Sleep better, live longer with the groundbreaking information and step-by-step program in this revolutionary book.Healthful sleep has been empirically proven to be the single most important factor in predicting longevity, more influential than diet, exercise, or heredity. And yet we are a sleep-sick society, ignorant of the facts of sleep--and the price of sleep deprivation. In this groundbreaking book, based on decades of study on the frontiers of sleep science, Dr. William Dement, founder and director of the Stanford University Sleep Research Center, explains what happens when we sleep, when we don't, and how we can reclaim the most powerful--and underrated--health miracle of all. Taking us on a fascinating tour of our sleeping body and mind, Dr. Dement reveals the price we have paid for ignoring sleep--an epidemic of heart disease, 33 percent of traffic-fatigue-related accidents, and immeasurable mental and psychological disadvantages. And he offers a hands-on prescription for vibrant good health and longevity, including...self-tests to determine how much sleep you really need...the role of prescription and over-the-counter sleeping aids...the latest research on how sleep affects the immune system...how to combat insomnia, snoring, and jet lag...plus information on sleep disorder clinics nationwide, Web sites, and more.Taking readers on a fascinating tour of our sleeping body and mind, Dr. William C. Dement reveals the price paid for ignoring sleep--an epidemic of heart disease, traffic-fatigue-related accidents (responsible for a full third of all traffic accidents), and immeasurable mental and psychological disadvantages. Offering a hands-on prescription for vibrant good health and longevity, THE PROMISE OF SLEEP includes self-tests to determine how much sleep you really need, full information on the role of prescription and over-the-counter sleeping aids, the latest research on how sleep affects the immune system, helpful methods for combating insomnia, snoring, and jet lag, plus information on sleep disorder clinics nationwide, sleep disorder Web sites, and more. -->

"In this landmark book, Robert O. Becker, M.D., a pioneer in the field of bioelectric science, presents a fascinating look at the role electricity plays in healing, challenging the traditional mechanistic model of the body. Colorful and controversial, this is a tale of engrossing research, scientific and medical politics, and breakthrough discoveries that offer new possibilities for fighting disease and harnessing the body's healing powers.

The best-selling books of Andrew Weil, "the guru of alternative medicine," (San Francisco Examiner) offer a comprehensive blend of traditional and alternative methods that help to achieve better health in the modern world. A bestseller in its original edition, The Natural Mind was Dr. Andrew Weil’s frst book and the philosophical basis for all of his resulting beliefs and tenets on health, healing, and the mind. Revised and updated for the twenty-first century, The Natural Mind suggests that the desire to alter consciousness periodically is an innate, normal human drive. A landmark in his career, and in America’s approach to the drug problem in general, The Natural Mind is essential reading for anyone interested in Andrew Weil’s philosophy of integrative medicine and optimum health.

Here David Oshinsky tells the gripping story of the polio terror and of the intense effort to find a cure, from the March of Dimes to the discovery of the Salk and Sabin vaccines--and beyond. Drawing on newly available papers of Jonas Salk, Albert Sabin and other key players, Oshinsky paints a suspenseful portrait of the race for the cure, weaving a dramatic tale centered on the furious rivalry between Salk and Sabin. He also tells the story of Isabel Morgan, perhaps the most talented of all polio researchers, who might have beaten Salk to the prize if she had not retired to raise a family.Oshinsky offers an insightful look at the National Foundation for Infantile Paralysis, which was founded in the 1930s by FDR and Basil O'Connor, it revolutionized fundraising and the perception of disease in America. Oshinsky also shows how the polio experience revolutionized the way in which the government licensed and tested new drugs before allowing them on the market, and the way in which the legal system dealt with manufacturers' liability for unsafe products. Finally, and perhaps most tellingly, Oshinsky reveals that polio was never the raging epidemic portrayed by the media, but in truth a relatively uncommon disease. But in baby-booming America--increasingly suburban, family-oriented, and hygiene-obsessed--the specter of polio, like the specter of the atomic bomb, soon became a cloud of terror over daily life.Both a gripping scientific suspense story and a provocative social and cultural history, Polio opens a fresh window onto postwar America.

An entertaining and accessible look at the role of serendipity in major medical and scientific breakthroughs of the twentieth century explains how chance and lucky accidents led to the discovery of such medical advances as penicillin, chemotherapy drugs, X-rays, Valium, the Pap smear, and Viagra.

"Bold, important and masterful . . . Marmot's message is not just timely, it's urgent."-The Washington Post Book WorldYou probably didn't realize that when you graduate from college you increase your lifespan, or that your co-worker who has a slightly better job is more likely to live a healthier life. In this groundbreaking book, epidemiologist Michael Marmot marshals evidence from nearly thirty years of research to demonstrate that status is not a footnote to the causes of ill health-it is the cause. He calls this effect the status syndrome.The status syndrome is pervasive. It determines the chances that you will succumb to heart disease, stroke, cancers, infectious diseases, even suicide and homicide. And the issue, as Marmot shows, is not simply one of income or lifestyle. It is the psychological experience of inequality-how much control you have over your life and the opportunities you have for full social participation-that has a profound effect on your health.The Status Syndrome will utterly change the way we think about health, society, and how we live our lives.

The Divided Mind is the crowning achievement of Dr. John E. Sarno's distinguished career as a groundbreaking medical pioneer, going beyond pain to address the entire spectrum of psychosomatic (mindbody) disorders.The interaction between the generally reasonable, rational, ethical, moral conscious mind and the repressed feelings of emotional pain, hurt, sadness, and anger characteristic of the unconscious mind appears to be the basis for mindbody disorders. The Divided Mind traces the history of psychosomatic medicine, including Freud's crucial role, and describes the psychology responsible for the broad range of psychosomatic illness. The failure of medicine's practitioners to recognize and appropriately treat mindbody disorders has produced public health and economic problems of major proportions in the United States.One of the most important aspects of psychosomatic phenomena is that knowledge and awareness of the process clearly have healing powers. Thousands of people have become pain-free simply by reading Dr. Sarno's previous books. How and why this happens is a fascinating story, and is revealed in The Divided Mind.

Hugely informative, practical, and uplifting. Healthy Aging is infused with the engaging candor and common sense that have made Dr. Andrew Weil our most trusted source on healthy living.EVERYTHING YOU NEED TO KNOW – The Anti-inflammatory following Dr. Weil's guide to eating right for a healthy lifestyle– Separating myth from fact about vitamins, herbs, hormones, anti-aging "medicines," and other would-be elixirs of life extension– Mastering exercise, breathing, and stress-management techniques to benefit your mind and body– Understanding the science behind the aging process– Sharing life lessons with your loved ones

Opium Drugs Culture studies Drug policy Poppy

IN THE WAR AGAINST DISEASES, THEY ARE THE SPECIAL FORCES. They always keep a bag packed. They seldom have more than twenty-four hours' notice before they are dispatched. The phone calls that tell them to head to the airport, sometimes in the middle of the night, may give them no more information than the country they are traveling to and the epidemic they will tackle when they get there.The universal human instinct is to run from an outbreak of disease. These doctors run toward it.They are the disease detective corps of the U.S. Centers for Disease Control and Prevention (CDC), the federal agency that tracks and tries to prevent disease outbreaks and bioterrorist attacks around the world. They are formally called the Epidemic Intelligence Service (EIS) -- a group founded more than fifty years ago out of fear that the Korean War might bring the use of biological weapons -- and, like intelligence operatives in the traditional sense, they perform their work largely in anonymity. They are not household names, but over the years they were first to confront the outbreaks that became known as hantavirus, Ebola virus, and AIDS. Now they hunt down the deadly threats that dominate our headlines: West Nile virus, anthrax, and SARS.In this riveting narrative, Maryn McKenna -- the only journalist ever given full access to the EIS in its fifty-three-year history -- follows the first class of disease detectives to come to the CDC after September 11, the first to confront not just naturally occurring outbreaks but the man-made threat of bioterrorism. They are talented researchers -- many with young families -- who trade two years of low pay and extremely long hours for the chance to be part of the group that has helped eradicate smallpox, push back polio, and solve the first major outbreaks of Legionnaires' disease, toxic shock syndrome, and "E. coli" O157.Urgent, exhilarating, and compelling, "Beating Back the Devil" goes with the EIS as they try to stop epidemics -- before the epidemics stop us.

In light of the health care crisis and the proliferation of HMOs, Dr. Weil has written a new introduction to this groundbreaking study of conventional and alternative medicine. Health and Healing presents the spectrum of alternative healing practices—holistic medicine, homeopathy, osteopathy, chiropractic, Chinese medicine—and outlines how they differ from conventional medicine.

Given the tensions and demands of medicine, highly successful physicians and surgeons rarely achieve equal success as prose writers. It is truly extraordinary that a major, international pioneer in the controversial field of transplant surgery should have written a spellbinding, and heart-wrenching, autobiography. Thomas Starzl grew up in LeMars, Iowa, the son of a newspaper publisher and a nurse. His father also wrote science fiction and was acquainted with the writer Ray Bradbury. Starzl left the family business to enter Northwestern University Medical School where he earned both and M.D. and a PhD. While he was a student, and later during his surgical internship at the Johns Hopkins Hospital, he began the series of animal experiments that led eventually to the world’s first transplantation of the human liver in 1963. Throughout his career, first at the University of Colorado and then at the University of Pittsburgh, he has aroused both worldwide admiration and controversy. His technical innovations and medical genius have revolutionized the field, but Starzl has not hesitated to address the moral and ethical issues raised by transplantation. In this book he clearly states his position on many hotly debated issues including brain death, randomized trials for experimental drugs, the costs of transplant operations, and the system for selecting organ recipients from among scores of desperately ill patients. There are many heroes in the story of transplantation, and many “puzzle people,” the patients who, as one journalist suggested, might one day be made entirely of various transplanted parts. They are old and young, obscure and world famous. Some have been taken into the hearts of America, like Stormie Jones, the brave and beautiful child from Texas. Every patient who receives someone else’s organ - and Starzl remembers each one - is a puzzle. “It was not just the acquisition of a new part,” he writes. “The rest of the body had to change in many ways before the gift could be accepted. It was necessary for the mind to see the world in a different way.” The surgeons and physicians who pioneered transplantation were also they too became puzzle people. “Some were corroded or destroyed by the experience, some were sublimated, and none remained the same.”

This classic work is a monumental, integrated view of man's search for an understanding of the inner reaches of the mind. In an account that is both exhaustive and exciting, the distinguished psychiatrist and author demonstrates the long chain of development—through the exorcists, magnetists, and hypnotists—that led to the fruition of dynamic psychiatry in the psychological systems of Janet, Freud, Adler, and Jung.

An astonishing new science called neuroplasticity is overthrowing the centuries-old notion that the human brain is immutable. Psychiatrist and psychoanalyst, Norman Doidge, M.D., traveled the country to meet both the brilliant scientists championing neuroplasticity and the people whose lives they’ve transformed - people whose mental limitations or brain damage were seen as unalterable. We see a woman born with half a brain that rewired itself to work as a whole, blind people who learn to see, learning disorders cured, IQs raised, aging brains rejuvenated, stroke patients learning to speak, children with cerebral palsy learning to move with more grace, depression and anxiety disorders successfully treated, and lifelong character traits changed. Using these marvelous stories to probe mysteries of the body, emotion, love, sex, culture, and education, Dr. Doidge has written an immensely moving, inspiring book that will permanently alter the way we look at our brains, human nature, and human potential.

In December 1995, Jean-Dominique Bauby, the forty-three-year-old editor of French Elle, suffered a massive stroke that left him completely and permanently paralyzed, a victim of "locked-in syndrome." Where once he had been renowned for his gregariousness and wit, Bauby now found himself imprisoned in an inert body, able to communicate only by blinking his left eye. The miracle is that in doing so he was able to compose this stunningly eloquent memoir, which was published two days before Bauby's death in 1996 and went on to become a number-one bestseller across Europe.The second miracle is that The Diving Bell and the Butterfly is less a record of affliction than it is a celebration of the liberating power of consciousness. In a voice that is by turns wistful and mischievous, angry and sardonic, Bauby tells us what it is like to spend a day with his children; to imagine lying in bed beside his lover; to conjure up the flavor of delectable meals even as he is fed by tube. Most of all, this triumphant book allows us to follow the flight of an indomitable spirit and to share its exultation at its own survival.

He would probably dispute it, but Gabor Maté is something of a compassion machine. Diligently treating the drug addicts of Vancouver's notorious Downtown Eastside with sympathy in his heart and legislative reform in mind can't be easy. But Maté never judges. His book is a powerful call-to-arms, both for the decriminalization of drugs and for a more sympathetic and informed view of addiction. As Maté observes, "Those whom we dismiss as 'junkies' are not creatures from a different world, only men and women mired at the extreme end of a continuum on which, here or there, all of us might well locate ourselves." In the Realm of Hungry Ghosts begins by introducing us to many of Dr. Maté's most dire patients who steal, cheat, sell sex, and otherwise harm themselves for their next hit. Maté looks to the root causes of addiction, applying a clinical and psychological view to the physical manifestation and offering some enlightening answers for why people inflict such catastrophe on themselves.Finally, he takes aim at the hugely ineffectual, largely U.S.-led War on Drugs (and its worldwide followers), challenging the wisdom of fighting drugs instead of aiding the addicts, and showing how controversial measures such as safe injection sites are measurably more successful at reducing drug-related crime and the spread of disease than anything most major governments have going. It's not easy reading, but we ignore his arguments at our peril. When it comes to combating the drug trade and the ravages of addiction, society can use all the help it can get. --Kim Hughes

For centuries, parasites have lived in nightmares, horror stories, and in the darkest shadows of science. Now award-winning writer Carl Zimmer takes us on a fantastic voyage into the secret parasite universe we actually live in but haven't recognized. He reveals not only that parasites are the most successful life-forms on Earth, but that they triggered the development of sex, shape ecosystems, and have driven the engine of evolution. In mapping the parasite universe, Zimmer makes the astonishing observation that most species are parasites, and that almost every animal, including humans, will at one time or another become the home of a parasite. Zimmer shows how highly evolved parasites are and describes the frightening and amazing ingenuity these commando invaders use to devour their hosts from the inside and control their behavior. The sinister Sacculina carcini makes its home in an unlucky crab and proceeds to eat everything but what the crab needs to put food in its mouth, which Sacculina then consumes. When Sacculina finally reproduces, it places its young precisely where the crab would nurture its own progeny, and then has the crab nurture the foster family members. Single-celled Toxoplasma gondi has an even more insidious role, for it can invade the human brain. There it makes men distrustful and less willing to submit to social mores. Women become more outgoing and warm-hearted. Why would a parasite cause these particular personality changes? It seems Toxoplasma wants its host to be less afraid, to be more prone to danger and a violent end -- so that, in the carnage, it will be able to move on to another host. From the steamy jungles of Costa Rica to the fetid parasite heaven of rebel-held southern Sudan, Zimmer tracks the genius of parasitic life and its impact on humanity. We hosts have developed remarkable defenses against the indomitable parasite: our mighty immune system, our culturally enforced habit of keeping clean, and, perhaps most intriguingly, sex. But this is not merely a book about the evil power of parasitism and how we must defend against it. On the contrary, Zimmer concludes that humankind itself is a new kind of parasite, one that preys on the entire Earth. If we are to achieve the sophistication of the parasites on display here in vivid detail, if we are to promote the flourishing of life in all its diversity as they do, we must learn the ways nature lives with itself, the laws of Parasite Rex.

Must children born with socially challenging anatomies have their bodies changed because others cannot be expected to change their minds? One of Us views conjoined twinning and other "abnormalities" from the point of view of people living with such anatomies, and considers these issues within the larger historical context of anatomical politics. Anatomy matters, Alice Domurat Dreger tells us, because the senses we possess, the muscles we control, and the resources we require to keep our bodies alive limit and guide what we experience in any given context. Her deeply thought-provoking and compassionate work exposes the breadth and depth of that context--the extent of the social frame upon which we construct the "normal." In doing so, the book calls into question assumptions about anatomy and normality, and transforms our understanding of how we are all intricately and inextricably joined.

What are hallucinogenic plants? How do they affect mind and body? Who uses them - and why? This unique Golden Guide surveys the role of psychoactive plants in primitive and civilized societies from early times to the present. The first nontechnical guide to both the cultural significance and physiological effects of hallucinogens, HALLUCINOGENIC PLANTS will fascinate general readers and students of anthropology and history as well as botanists and other specialists. All of the wild and cultivated species considered are illustrated in brilliant full color.

The Mind of a Mnemonist is a rare phenomenon - a scientific study that transcends its data and, in the manner of the best fictional literature, fashions a portrait of an unforgettable human being."

Today a brain scan reveals our thoughts, moods, and memories as clearly as an X-ray reveals our bones. We can actually observe a person's brain registering a joke or experiencing a painful memory. Drawing on the latest imaging technology and the expertise of distinguished scientists, Rita Carter explores the geography of the human brain. Her writing is clear, accessible, witty, and the book's 150 illustrations—most in color—present an illustrated guide to that wondrous, coconut-sized, wrinkled gray mass we carry inside our heads.Mapping the Mind charts the way human behavior and culture have been molded by the landscape of the brain. Carter shows how our personalities reflect the biological mechanisms underlying thought and emotion and how behavioral eccentricities may be traced to abnormalities in an individual brain. Obsessions and compulsions seem to be caused by a stuck neural switch in a region that monitors the environment for danger. Addictions stem from dysfunction in the brain's reward system. Even the sense of religious experience has been linked to activity in a certain brain region. The differences between men and women's brains, the question of a "gay brain," and conditions such as dyslexia, autism, and mania are also explored.Looking inside the brain, writes Carter, we see that actions follow from our perceptions, which are due to brain activity dictated by a neuronal structure formed from the interplay between our genes and the environment. Without sidestepping the question of free will, Carter suggests that future generations will use our increasing knowledge of the brain to "enhance those mental qualities that give sweetness and meaning to our lives, and to eradicate those that are destructive."

Few of the great stories of medicine are as palpably dramatic as the invention of open-heart surgery, yet, until now, no journalist has ever brought all of the thrilling specifics of this triumph to life.This is the story of the surgeon many call the father of open-heart surgery, Dr. C. Walton Lillehei, who, along with colleagues at University Hospital in Minneapolis and a small band of pioneers elsewhere, accomplished what many experts considered to be an impossible feat: He opened the heart, repaired fatal defects, and made the miraculous routine.Acclaimed author G. Wayne Miller draws on archival research and exclusive interviews with Lillehei and legendary pioneers such as Michael DeBakey and Christiaan Barnard, taking readers into the lives of these doctors and their patients as they progress toward their landmark achievement. In the tradition of works by Richard Rhodes and Tracy Kidder, King of Hearts tells the story of an important and gripping piece of forgotten science history.

Winner, 2008 Book of the Year, End Malaria Awards, Malaria Foundation International Malaria sickens hundreds of millions of people―and kills one to three million―each year. Despite massive efforts to eradicate the disease, it remains a major public health problem in poorer tropical regions. But malaria has not always been concentrated in tropical areas. How did other regions control malaria and why does the disease still flourish in some parts of the globe? From Russia to Bengal to Palm Beach, Randall Packard’s far-ranging narrative traces the natural and social forces that help malaria spread and make it deadly. He finds that war, land development, crumbling health systems, and globalization―coupled with climate change and changes in the distribution and flow of water―create conditions in which malaria's carrier mosquitoes thrive. The combination of these forces, Packard contends, makes the tropical regions today a perfect home for the disease. Authoritative, fascinating, and eye-opening, this short history of malaria concludes with policy recommendations for improving control strategies and saving lives.

The Uses of Haiti tells the truth about uncomfortable matters—uncomfortable, that is, for the structures of power and the doctrinal framework that protects them from scrutiny. It tells the truth about what has been happening in Haiti, and the US role in its bitter fate .—Noam Chomsky, from the introduction In this third edition of the classic The Uses of Haiti , Paul Farmer looks at what has happened to the health of the poor in Haiti since the coup. Winner of a McArthur Genius Award, Paul Farmer is a physician and anthropologist who has worked for 25 years in Haiti, where he serves as medical director of a hospital serving the rural poor. He is the subject of the Tracy Kidder biography, Mountains Beyond Mountains .

When Rats, Lice and History appeared in 1935, Hans Zinsser was a highly regarded Harvard biologist who had never written about historical events. Although he had published under a pseudonym, virtually all of his previous writings had dealt with infections and immunity and had appeared either in medical and scientific journals or in book format. Today he is best remembered as the author of Rats, Lice, and History , which gone through multiple editions and remains a masterpiece of science writing for a general readership. To Zinsser, scientific research was high adventure and the investigation of infectious disease, a field of battle. Yet at the same time he maintained a love of literature and philosophy. His goal in Rats, Lice and History was to bring science, philosophy, and literature together to establish the importance of disease, and especially epidemic infectious disease, as a major force in human affairs. Zinsser cast his work as the "biography" of a disease. In his view, infectious disease simply represented an attempt of a living organism to survive. From a human perspective, an invading pathogen was abnormal; from the perspective of the pathogen it was perfectly normal. This book is devoted to a discussion of the biology of typhus and history of typhus fever in human affairs. Zinsser begins by pointing out that the louse was the constant companion of human beings. Under certain conditions–to wash or to change clothing–lice proliferated. The typhus pathogen was transmitted by rat fleas to human beings, who then transmitted it to other humans and in some strains from human to human. Rats, Lice and History is a tour de force. It combines Zinsser's expertise in biology with his broad knowledge of the humanities

Level 4: Virus Hunters of the CDC, is a memoir by America's most famous virus researchers. "Level 4" is the highest degree of laboratory containment for isolation and experimentation on microbiological organisms. Level-4 organisms produce lethal illnesses in humans and, for the most part, have no treatment and no prevention. Among the most infamous are the hemorrhagic viral diseases Ebola and Lassa Fever.This is the story of those who hunt the emerging diseases making global headlines. Join husband-and-wife team Dr. Joseph B. McCormick and Dr. Susan Fisher-Hoch in their search for those who may be infected by these lethal viruses. You will travel through equatorial Africa, the ghettos and rainforests of Brazil, and through settlements in northern Pakistan. Both Dr. McCormick and Dr. Fisher-Hoch will offer their scientific knowledge about how and why these viruses are so lethal to humans and what can be done to prevent any kind of devastating epidemic from ever breaking out. The book shows how dedication, intelligence and courage can prevail--and give us hope for the future of global health. 1570362777 , 978-1570362774

The definitive account of epidemics in our time, from the Pulitzer Prize-winning public heath expert Laurie Garrett.A New York Times notable bookUnpurified drinking water. Improper use of antibiotics. Local warfare. Massive refugee migration. Changing social and environmental conditions around the world have fostered the spread of new and potentially devastating viruses and diseases—HIV, Lassa, Ebola, and others. Laurie Garrett takes you on a fifty-year journey through the world's battles with microbes and examines the worldwide conditions that have culminated in recurrent outbreaks of newly discovered diseases, epidemics of diseases migrating to new areas, and mutated old diseases that are no longer curable. She argues that it is not too late to take action to prevent the further onslaught of viruses and microbes, and offers possible solutions for a healthier future.

One of the nation's leading surgeons tells of his experiments that are revolutionizing the treatment of cancer. After meeting a man whose inoperable cancer spontaneously and mysteriously disappeared in 1968, Dr. Rosenberg began his quest for a cure for cancer. A rare view of the trials and triumphs of scientific discovery.

The struggle to perform well is universal: each one of us faces fatigue, limited resources, and imperfect abilities in whatever we do. But nowhere is this drive to do better more important than in medicine, where lives are on the line with every decision. In his new book, Atul Gawande explores how doctors strive to close the gap between best intentions and best performance in the face of obstacles that sometimes seem insurmountable. Gawande's gripping stories of diligence, ingenuity, and what it means to do right by people take us to battlefield surgical tents in Iraq, to labor and delivery rooms in Boston, to a polio outbreak in India, and to malpractice courtrooms around the country. He discusses the ethical dilemmas of doctors participation in lethal injections, examines the influence of money on modern medicine, and recounts the astoundingly contentious history of hand washing. And as in all his writing, Gawande gives us an inside look at his own life as a practicing surgeon, offering a searingly honest firsthand account of work in a field where mistakes are both unavoidable and unthinkable. At once unflinching and compassionate, Better is an exhilarating journey narrated by arguably the best nonfiction doctor-writer around (Salon). Gawande's investigation into medical professionals and how they progress from merely good to great provides rare insight into the elements of success, illuminating every area of human endeavor.

The hilarious novel of the healing arts that reveals everything your doctor never wanted you to know. Six eager interns—they saw themselves as modern saviors-to-be. They came from the top of their medical school class to the bottom of the hospital staff to serve a year in the time-honored tradition, racing to answer the flash of on-duty call lights and nubile nurses. But only the Fat Man—the Clam, all-knowing resident—could sustain them in their struggle to survive, to stay sane, to love and even to be doctors when their harrowing year was done.

“It manages to delight, and frequently to entrance, old and new readers [and] continues to engage our hearts and minds today with an indescribably brand of affectionate sympathy.”—F. Gonzalez-Crussi, from the IntroductionAn international bestseller, translated into eighteen languages, Paul de Kruif’s classic account of the first scientists to see and learn about the microscopic world continues to fascinate new readers. This is a timeless dramatization of the scientists, bacteriologists, doctors, and medical technicians who discovered the microbes and invented the vaccines to counter them. De Kruif writes about how seemingly simple but really fundamental discovers of science—for instance, how a microbe was first viewed in a clear drop of rain water, and when, for the first time, Louis Pasteur discovered that a simple vaccine could save a man from the ravages of rabies by attacking the microbes that cause it.

A classic work that has revolutionized thinking throughout the Western world about the nature of the psychiatric profession and the moral implications of its practices. "Bold and often brilliant.”—Science "It is no exaggeration to state that Szasz's work raises major social issues which deserve the attention of policy makers and indeed of all informed and socially conscious Americans...Quite probably he has done more than any other man to alert the American public to the potential dangers of an excessively psychiatrized society.”—Edwin M. Schur, Atlantic

Awakenings is a 1973 non-fiction book by Oliver Sacks. It recounts the life histories of those who had been victims of the 1920s encephalitis lethargica epidemic. Sacks chronicles his efforts in the late 1960s to help these patients at the Beth Abraham Hospital in the Bronx, New York.

In this fresh approach to the history of the Black Death, world-renowned scholar John Hatcher re-creates everyday life in a mid-fourteenth century rural English village. By focusing on the experiences of ordinary villagers as they lived-and died-during the Black Death (1345-50), Hatcher vividly places the reader directly inside those tumultuous times and describes in fascinating detail the day-to-day existence of people struggling with the tragic effects of the plague. Dramatic scenes portray how contemporaries must have felt and thought about these momentous events: what they knew and didn't know about the horrors of the disease, what they believed about death and God's vengeance, and how they tried to make sense of it all despite frantic rumors, frightening tales, and fearful sermons.

Román vypráví o osudu mukla a věčného vyhnance Olega Kostoglotova, který se v polovině padesátých let přichází léčit na taškentskou onkologickou kliniku. Je to v době, kdy Stalin je již dva roky mrtev, Berija popraven a kdy se začínají objevovat první nesmělé náznaky změn. Na onkologické klinice se setkávají členové strany i vyhnanci, národy, které sem Stalin vysídlil, i původní obyvatelé, lékaři i pacienti. Jejich společným nepřítelem je rakovina: nemoc, smrt, konec života... V blízkosti smrti padají všechny dosavadní jistoty, všechny plány, všechna privilegia. A v tomto světě rozehrává Solženicyn příběhy svých hrdinů, jejich lásek a nadějí. Nádory, sarkomy a metanoblastomy jsou nejen krutou skutečností, s níž se potýkají hrdinové románu i lékaři, ale i metaforou pro rakovinu lži, přetvářky, násilí a útlaku, která metastázuje do všech vrstev ruské společnosti.

The first edition of Jim Watson's classic textbook Molecular Biology of the Gene appeared in 1965. This new edition, written with five new authors, has been brought fully up to date, and incorporates insights very recently derived from genome sequencing in a variety of organisms. The book isan authoritative and comprehensive survey of the fundamentals of molecular biology, from basic mechanisms to the elaborate role of gene regulation in embryonic development and evolution. Although updated, the twentyDSone chapters of the new edition retain the distinctive and celebrated features ofthe original work, including introductory chapters on the history of genetics and molecular biology and an emphasis throughout on the chemical underpinnings of molecular biology. The new team of authors brings to this edition awardDSwinning teaching experience and outstanding research achievements.By revealing the intellectual framework and experimental approaches that made new discoveries in the field possible, the new edition highlights the significance of the molecular approach for all of biology.

For more than 3000 years, hundreds of millions of people have died or been left permanently scarred or blind by the relentless, incurable disease called smallpox. In 1967, Dr. D.A. Henderson became director of a worldwide campaign to eliminate this disease from the face of the earth.This spellbinding book is Dr. Henderson’s personal story of how he led the World Health Organization’s campaign to eradicate smallpox—the only disease in history to have been deliberately eliminated. Some have called this feat "the greatest scientific and humanitarian achievement of the past century."In a lively, engrossing narrative, Dr. Henderson makes it clear that the gargantuan international effort involved more than straightforward mass vaccination. He and his staff had to cope with civil wars, floods, impassable roads, and refugees as well as formidable bureaucratic and cultural obstacles, shortages of local health personnel and meager budgets. Countries across the world joined in the effort; the United States and the Soviet Union worked together through the darkest cold war days; and professionals from more than 70 nations served as WHO field staff. On October 26, 1976, the last case of smallpox occurred. The disease that annually had killed two million people or more had been vanquished–and in just over ten years.The story did not end there. Dr. Henderson recounts in vivid detail the continuing struggle over whether to destroy the remaining virus in the two laboratories still that held it. Then came the startling discovery that the Soviet Union had been experimenting with smallpox virus as a biological weapon and producing it in large quantities. The threat of its possible use by a rogue nation or a terrorist has had to be taken seriously and Dr. Henderson has been a central figure in plans for coping with it.New methods for mass smallpox vaccination were so successful that he sought to expand the program of smallpox immunization to include polio, measles, whooping cough, diphtheria, and tetanus vaccines. That program now reaches more than four out of five children in the world and is eradicating poliomyelitis.This unique book is to be treasured—a personal and true story that proves that through cooperation and perseverance the most daunting of obstacles can be overcome.

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

This comprehensive medical resource, The Merck Manual - - Third Home Edition , extensively covers health care for newborns, the elderly, and everyone in between. The new Third Home Edition provides the same authoritative information doctors have relied on in The Merck Manual, for more than a century, in easy-to-understand, everyday language. Previous editions have sold more than 3 million copies. Written by more than 200 internationally respected medical experts, this new edition of the world's bestselling reference presents in-depth information for medical situations, including:AgingGynecological DisordersHeart diseaseDigestive disordersCancerNutrition problemsAIDSHormonal problemsInfections and immunizationsNeurological DisordersPediatric DisordersMen's, women's and children's health issuesMental health disordersAccidents and injuriesCare for the dying And much more...

In recent years, malaria has emerged as a cause célèbre for voguish philanthropists. Bill Gates, Bono, and Laura Bush are only a few of the personalities who have lent their names—and opened their pocketbooks—in hopes of curing the disease. Still, in a time when every emergent disease inspires waves of panic, why aren’t we doing more to eradicate one of our oldest foes? And how does a parasitic disease that we’ve known how to prevent for more than a century still infect 500 million people every year, killing nearly 1 million of them?In The Fever , the journalist Sonia Shah sets out to answer these questions, delivering a timely, inquisitive chronicle of the illness and its influence on human lives. Through the centuries, she finds, we’ve invested our hopes in a panoply of drugs and technologies, and invariably those hopes have been dashed. From the settling of the New World to the construction of the Panama Canal, through wars and the advances of the Industrial Revolution, Shah tracks malaria’s jagged ascent and the tragedies in its wake, revealing a parasite every bit as persistent as the insects that carry it. With distinguished prose and original reporting from Panama, Malawi, Cameroon, India, and elsewhere, The Fever captures the curiously fascinating, devastating history of this long-standing thorn in the side of humanity.