Sue Armstrong

All of us have a most remarkable gene lurking in our DNA. Its job is to protect us from cancer. This gene, known simply as p53, constantly scans our cells to ensure that when they grow and divide as part of the routine maintenance of our bodies, they do so without mishap. If a cell makes a mistake in copying its DNA during the process, p53 repairs it before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control (as happens in cancer), p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or handicapped by some other fault in the system. Not surprisingly, p53 is the most studied single gene in history.p53: The Gene that Cracked the Cancer Code tells the story of the discovery of the gene and of medical science's mission to unravel its mysteries and get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, the book reveals the excitement of the hunt for new cures--the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is at the cutting edge. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.

The question of how and why organisms age has teased scientists for centuries. There are myriad competing theories, from the idea that aging is a simple wear and tear process, like the rusting of a car, to the belief that aging and death are genetically programmed and controlled. In fact, there is no clearly defined limit to life, and no single, predictable program playing itself different things are happening within and between tissues, and each system or organ accumulates damage at its own pace, according to the kind of insults imposed on it by daily living. Sometime before 2020, the number of people over sixty-five worldwide will, for the first time, be greater than the number of 0-4 year olds; and by 2050 there are likely to be 2.5 times as many older people in the world as toddlers. Sue Armstrong tells the story of society's quest to understand aging through the eyes of the scientists themselves, as well as through the "ordinary" people who exemplify the mysteries of ageing--from those who suffer from the premature aging condition, Hutchinson-Gilford syndrome, to people still running marathons in their 80s. Borrowed Time will investigate such mind-boggling experiments as transfusing young blood into old rodents, and research into transplanting the first human head, among many others. It will explore where science is taking us and what issues are being raised from a psychological, philosophical and ethical perspective, through interviews with, and profiles of, key scientists in the field and the people who represent interesting and important aspects of aging.

A Matter of Life and Death profiles some of the world's most eminent and pioneering pathologists. This is a hidden world, yet one we will all inevitably encounter at some time in our lives, for pathology lies at the cornerstone of modern medicine. It is pathologists who are responsible for recognising new diseases such as AIDS, SARS or bird flu, and for diagnosing which cancer a patient is suffering from. And it is pathologists who must explain the cause of death at the autopsy table. A Matter of Life and Death tells fascinating stories of mysterious illnesses and miraculous scientific breakthroughs. But it is also crammed full of extraordinary characters - from the forensic anthropologist with his own Body Farm in Tennessee to the doctor who had a heart-and-lung transplant and ended up using her own lungs for research.